GlycoMark Test, Dr. Weyrich's Naturopathic Functional Medicine Notebook

Test Indications of GlycoMark Test

According to Go to Medicare Medicare "the GlycoMark assay is not considered reasonable and necessary for the management of diabetes or the prevention of diabetic complications, and is not covered by Medicare. There are NO ICD-10 Codes that support medical necessity."

Go to Proponents Proponents of the test cite personalized diabetes care benefits such as:

Two-week measure of average daily maximum blood glucose, which augments the three-month measure of average blood glucose given by the A1c test. [Dungan2006] points out, "in contrast, A1c is an index of average glucose over a much longer period of time (2-3 months), encompassing both hyperglycemia and hypoglycemia."
Can help identify patients who may need therapy changes despite a "good" A1c, for example patients with poor postprandial glucose control.
Low 1,5-AG levels can help stratify patients at higher risk of diabetes complications.

Labs Performing GlycoMark Test Test

Name of Lab	Lab Code	Estimated Cost	Processing Time	Comments
Sonora Quest
Labcorp

Costs cited are subject to change and may be reduced by insurance or cash discounts and increased by sample collection fees.

Hypotheses regarding GlycoMark Test

Dr. Weyrich considers the GlycoMark test to be most useful when A1c suggests reasonable control of average blood glucose. If A1c is excessively high, there is no pointing doing a GlycoMark test, since we already know that if the average glucose is already too high, it follows that there must also be high peak glucose levels.

References regarding GlycoMark Test

[Dungan2006] Kathleen M. Dungan et al. 1,5-Anhydroglucitol and Postprandial Hyperglycemia as Measured by Continuous Glucose Monitoring System in Moderately Controlled Patients With Diabetes. Diabetes Care 29:1214 -1219, 2006. Full text: Full text: https://diabetesjournals.org/care/article/29/6/1214/24997/1-5-Anhydroglucitol-and-Postprandial-Hyperglycemia

Full text: https://diabetesjournals.org/care/article/29/6/1214/24997/1-5-Anhydroglucitol-and-Postprandial-Hyperglycemia

https://diabetesjournals.org/care/article/29/6/1214/24997/1-5-Anhydroglucitol-and-Postprandial-Hyperglycemia Accessed: March 20, 2023.

Unless specifically noted above, references used in the construction of this web page include the following:

[FMU] Lecture notes from Functional Medicine University.

[SCNM] Lecture notes from Southwest College of Naturopathic Medicine.

[UT] Lecture notes from the University of Tennessee graduate programs in Chemistry, Microbiology, and Biochemistry.