Dr. Weyrich's Naturopathic Functional Medicine Notebook is a collection of information on topics of interest to Dr. Weyrich that may be of interest to the world wide audience. Due to limitations of time, not all information that Dr. Weyrich knows or would like to further research is published here. Dr. Weyrich welcomes financial contributions to support specific research topics, as well as copies of non-free access journal articles for him to review on a topic. Constructive criticism is also welcome.


Differential Diagnosis of Liver Congestion


Pathophysiology of Liver Congestion

It is observed that disturbed liver function is significantly higher among untreated hypothyroid patients than among those patients who have been properly treated. This disturbed liver function is manifested in elevated liver enzymes and dyslipidemia [Barnes], [Starr2005, pg 139].

In addition, since the liver is primarily responsible for the conversion of T4 to T3, impaired liver function is magnified by further decrease in thyroid function [Kharrazian2010, pg 11].


Hypotheses regarding Liver Congestion

The liver is very metabolically active and consumes large amounts of ATP energy. As a result, the liver is sensitive to mitochondrial dysfunction such as occurs in hypothyroid conditions. In addition, myxedema in the liver may interfere with the liver's secretion of bile into the canaliculi by compressing the canaliculi [Hertoghe1914], [Starr2005, pg 139].

References for Liver Congestion