Dr. Weyrich's Naturopathic Functional Medicine Notebook is a collection of information on topics of interest to Dr. Weyrich that may be of interest to the world wide audience. Due to limitations of time, not all information that Dr. Weyrich knows or would like to further research is published here. Dr. Weyrich welcomes financial contributions to support specific research topics, as well as copies of non-free access journal articles for him to review on a topic. Constructive criticism is also welcome.


Overview of Crohn's Disease and Ulcerative Colitis

Crohn's disease and ulcerative colitis are inflammatory bowel conditions.

Low Dose Naltrexone may be particularly effective in treating Crohn's disease. Dr. Weyrich considers this to be the first-line treatment, as it is more cost-effecive and has a lower side effect profile than other conventional treatments such as aminosalicylates and infliximab.

Complimentary and alternative treatments for Crohn's disease and ulcerative colitis that are considered below include:

  • Immune System Balancing
  • Low Dose Naltrexone
  • Neurotransmitter Balancing

Etiology of Crohn's Disease and Ulcerative Colitis

The definitive cause of Crohn's disease is unknown. Keeping in mind that association does not necessarily distinguish between cause and effect, the following factors have been associated with Crohn's disease, in no particular order:
  • The British gastroenterologist Andrew Wakefield has associated Crohn's Disease with the MMR (Measles, Mumps, Rubella) vaccine [Shaw2008].
  • Inflammatory process mediated by estrogen receptors: [Risbridger2007] has pointed out the inflammatory effect of stimulating estrogen-receptor-alpha (ER-A) in inflammatory bowel disease, and the anti-inflammatory effect of stimulating estrogen-receptor-beta (ER-B). Both estriol and the naturally occurring substance genistein have been shown to selectively stimulate ER-B.

Treatment of Crohn's Disease and Ulcerative Colitis

Please see conventional, complimentary and alternative medical treatments for important background information regarding the different types of medical treatments discussed below.

Naturopathic, Complimentary and Alternative Treatments

Immune System Balancing

[McCulley2018, pp 28, 33, 60, 89] reports that Crohn's disease is a TH1- and TH17-dominant, localized, autoimmune disorder, and proposes an approach to treating this disease, which should be supervised by a properly trained medical professional. Dr. Weyrich has considerable interest in this topic, but has not treated any cases of Crohn's disease with Immune System Balancing.

Please see What is Immune System Balancing? for more information.

Low Dose Naltrexone (LDN)

The late Dr. Bernard Bihari [Bihari2003], [Bihari2013], who discovered the benefits of low dose naltrexone in 1986, reported extraordinary results treating a variety of autoimmune and neuroinflammatory conditions [Bihari2003], [Bihari2013]. In particular, Low Dose Naltrexone (4.5mg/day) has been shown to have an immune-balancing effect that benefits Crohn's disease, with a 67% remission rate [Farmer1985], [Smith2007], [Smith2011], [Smith2013], [LDN]. [LDN_Autoimmune] reports that Dr. Bernard Bihari treated a cohort of eight patients having Crohn's disease with LDN, obtaining remission of symptoms within 14-21 days in all cases. However, [Segal2014] cautions that additional research is necessary.

Dr. Weyrich has been trained in the use of Low Dose Naltrexone (LDN). However, Dr. Weyrich has not treated any cases of Crohn's disease with LDN.

Please see What is Low Dose Naltrexone? for more information.

Neurotransmitter Balancing

Neuro Research [Hinz2015] reports that Crohn's disease can be benefited by balancing neurotransmitter levels in the body.

Dr. Weyrich has been trained in neurotransmitter balancing protocols, but has not treated Crohn's disease using this technique.

Please see What is Neurotransmitter Balancing? for more information.


References for Crohn's Disease and Ulcerative Colitis