Dr. Weyrich's Naturopathic Functional Medicine Notebook is a collection of information on topics of interest to Dr. Weyrich that may be of interest to the world wide audience. Due to limitations of time, not all information that Dr. Weyrich knows or would like to further research is published here. Dr. Weyrich welcomes financial contributions to support specific research topics, as well as copies of non-free access journal articles for him to review on a topic. Constructive criticism is also welcome.


Overview of Biofilms

Biofilms, which are specialized colonies of bacteria and/or fungi, appear in many human disease processes, and are particularly hard to effectively treat. Combination drugs and/or combinations of herbal products used simultaneously are particularly useful in treating these biofilms. For example, many biofilms consist of outer layers of aerobic bacteria with an interior core of anaerobic bacteria. Effective treatment of such a biofilm must target both varieties of bacteria, as well as targeting various processes required to build and maintain biofilms, such as quorum sensing, Multiple Drug Resistant Efflux Pumps (MDR).

Disorders associated with biofilms include [BERGNER2016]:

  • Chronic lung infections
  • Cystic fibrosis
  • Endocarditis
  • Chronic osteomyelitis
  • Chronic otitis media
  • Chronic sinusitis
  • Chronic (non-healing) wounds
  • Infectious kidney stones
  • Various implants - pacemakers, artificial joints, pins, heart valves, stents, vascular grafts
  • Dental plaque
  • Periodontal disease
  • MRSA
  • H. Pylori
  • Tooth abscess
  • Bacterial vaginosis [Machado 2016]
  • Bladder infections
  • Borrelia

References for Biofilms