Dr. Weyrich's Naturopathic Functional Medicine Notebook is a collection of information on topics of interest
to Dr. Weyrich that may be of interest to the world wide audience.
Due to limitations of time, not all information that Dr. Weyrich knows or would like to further research is
Dr. Weyrich welcomes financial contributions to support specific research topics, as well as copies of
non-free access journal articles for him to review on a topic.
Constructive criticism is also welcome.
Overview of Peripheral Neuropathy
Peripheral neuropathy is any damage or dysfunction of the nerves outside the spinal cord and brain.
It can occur anywhere in the body - it can be localized or widespread.
Complimentary and alternative treatments for peripheral neuropathy that are considered below include:
Low Dose Naltrexone
Etiology of Peripheral Neuropathy
Peripheral Neuropathy is generally classified as either widespread or local, as discussed below.
Widespread Peripheral Neuropathy
Widespread peripheral neuropathy is usually due to some systemic problem, for example:
Diabetes, porphyria, uremia, or other systemic metabolic disease
Drug, alcohol, or toxin side effects
Too much or too little of the various B vitamins (or an imbalance)
Autoimmune diseases such as multiple sclerosis
Local Peripheral Neuropathy
Local peripheral neuropathy is usually due to truama, for example:
Local trauma, e.g. crush injuries
Spinal column subluxations, fixations, or degenerative disc disease that results in
compression of nerve roots exiting segments of the spine
Brachial, lumbar or sacral nerve plexus damage
Repetitive strain injuries
Foot drop (peroneal nerve)
Wrist drop (radial nerve)
Diagnosis of Peripheral Neuropathy
Peripheral neuropathy can cause many symptoms, including:
Pain or tingling
Loss of sense of touch (numbness)
Loss of muscle or organ function.
Autonomic nervous system disruption:
Gastrointestinal problems (gastroparesis)
Treatment of Peripheral Neuropathy
Sometimes treatment can at least partially cure, but often treatment can only slow or stop the progression
of the disease process. The sooner treatment is begun, the better the prognosis.
In general, treatment is based on identifying and treating the cause:
In the following paragraphs, NNT is the Number of patients Needed to Treat in order to get a
30-50% (moderate) reduction in pain;
NNH is the Number of Patients needed to treat in order to cause Harm sufficient for the patient to
The first number represents the effectiveness of the treatment and the second number represents the
A recent meta-analysis [Finnerup2015] identified the following palliative drugs as being
first-line, second line, or third line based on effectiveness and safety profile:
Naturopathic, Complimentary and Alternative Treatments
Low Dose Naltrexone (LDN)
[LdnResearchTrust_conditions] reports that peripheral neuropathy
is a condition that LDN could help.
Dr. Weyrich has been trained in the use of Low Dose Naltrexone (LDN).
However, Dr. Weyrich has not treated any cases of peripheral neuropathy