Dr. Weyrich's Naturopathic Functional Medicine Notebook is a collection of information on topics of interest to Dr. Weyrich that may be of interest to the world wide audience. Due to limitations of time, not all information that Dr. Weyrich knows or would like to further research is published here. Dr. Weyrich welcomes financial contributions to support specific research topics, as well as copies of non-free access journal articles for him to review on a topic. Constructive criticism is also welcome.


Overview of MPTP (N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Toxicity)

The compound N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) has been identified in underground laboratory preparations of a potent analog of meperidine (Demerol). Sporadic outbreaks of MPTP-induced parkinsonism have occurred among street-drug abusers. Treatment includes cessation of exposure, as well as treatments similar to Parkinson's disease.

Differential Diagnosis of MPTP (N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Toxicity)

  • catatonic schizophrenia

Pathophysiology of MPTP (N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Toxicity)

MPTP is a potent inhibitor of complex I of the mitochondrial respiratory chain, and is associated with L-DOPA-responsive parkinsonism [https://academic.oup.com/bmb/article/114/1/39/246438].


References for MPTP (N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine Toxicity)